<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c4b77-e537-7a8b-b44f-6e4fb1b931fb,g:8e0bb32f-1981-436e-b6ac-a35e530186c3-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="algn-20251231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019c4b77-e6fe-7c0f-bf7b-9d978ddf2dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c4b77-e6fe-7a4f-a38a-fb6e04a9546e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019c4b77-e6fe-7c0f-bf7b-9d978ddf2dbf" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c4b77-e6fe-7a4f-a38a-fb6e04a9546e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019c4b77-e6fe-785d-a6d5-01c38591251b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019c4b77-e6fe-7c0f-bf7b-9d978ddf2dbf" xlink:to="loc_us-gaap_CostOfRevenue_019c4b77-e6fe-785d-a6d5-01c38591251b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c4b77-e6fe-7427-9913-54289cfb9d76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019c4b77-e6fe-723e-b92e-1c49927e9459" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c4b77-e6fe-7427-9913-54289cfb9d76" xlink:to="loc_us-gaap_GrossProfit_019c4b77-e6fe-723e-b92e-1c49927e9459" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-7838-a2cd-a2a428a5eae9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c4b77-e6fe-7427-9913-54289cfb9d76" xlink:to="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-7838-a2cd-a2a428a5eae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-77f4-8f79-a0da36bd9ad4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019c4b77-e6fe-73e6-baab-0da5e27f3138" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-77f4-8f79-a0da36bd9ad4" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019c4b77-e6fe-73e6-baab-0da5e27f3138" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_RestructuringAndOtherCharges_019c4b77-e6fe-7885-82c2-b137ea7ea076" xlink:href="algn-20251231.xsd#algn_RestructuringAndOtherCharges"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-77f4-8f79-a0da36bd9ad4" xlink:to="loc_algn_RestructuringAndOtherCharges_019c4b77-e6fe-7885-82c2-b137ea7ea076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019c4b77-e6fe-7b71-8446-26b0e0645e17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-77f4-8f79-a0da36bd9ad4" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019c4b77-e6fe-7b71-8446-26b0e0645e17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_019c4b77-e6fe-77a7-866a-b5375cae5c50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c4b77-e6fe-77f4-8f79-a0da36bd9ad4" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_019c4b77-e6fe-77a7-866a-b5375cae5c50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e6fe-7e5d-b10a-37d873e9f47e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c4b77-e6fe-7dc0-815c-50c7affb2aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e6fe-7e5d-b10a-37d873e9f47e" xlink:to="loc_us-gaap_OperatingIncomeLoss_019c4b77-e6fe-7dc0-815c-50c7affb2aaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_InterestIncomeAndOtherIncomeExpenseNet_019c4b77-e6fe-7f14-97f1-9167f8727c33" xlink:href="algn-20251231.xsd#algn_InterestIncomeAndOtherIncomeExpenseNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e6fe-7e5d-b10a-37d873e9f47e" xlink:to="loc_algn_InterestIncomeAndOtherIncomeExpenseNet_019c4b77-e6fe-7f14-97f1-9167f8727c33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c4b77-e6fe-76e7-9cbe-1c7b9d456fe2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e6fe-7ab9-aee8-802d73291c13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c4b77-e6fe-76e7-9cbe-1c7b9d456fe2" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e6fe-7ab9-aee8-802d73291c13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e6fe-7ddd-a9e8-ac1b57ecaa55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c4b77-e6fe-76e7-9cbe-1c7b9d456fe2" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e6fe-7ddd-a9e8-ac1b57ecaa55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_InterestIncomeAndOtherIncomeExpenseNet_019c4b77-e6fe-7a81-8a3e-87da9e40e028" xlink:href="algn-20251231.xsd#algn_InterestIncomeAndOtherIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_019c4b77-e6fe-7e3f-952f-0d4f47368f55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_InterestIncomeAndOtherIncomeExpenseNet_019c4b77-e6fe-7a81-8a3e-87da9e40e028" xlink:to="loc_us-gaap_InterestIncomeOther_019c4b77-e6fe-7e3f-952f-0d4f47368f55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019c4b77-e6fe-7f4f-a4fb-b44805eb9592" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_InterestIncomeAndOtherIncomeExpenseNet_019c4b77-e6fe-7a81-8a3e-87da9e40e028" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019c4b77-e6fe-7f4f-a4fb-b44805eb9592" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="algn-20251231.xsd#CONSOLIDATEDSTATEMENTOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c4b77-e6fe-7340-88d9-3d7af4588ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019c4b77-e6fe-7fcd-a47f-6fa98fdd9d1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c4b77-e6fe-7340-88d9-3d7af4588ea4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019c4b77-e6fe-7fcd-a47f-6fa98fdd9d1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c4b77-e7d1-7782-acdd-d108628e6111" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c4b77-e6fe-7340-88d9-3d7af4588ea4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c4b77-e7d1-7782-acdd-d108628e6111" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c4b77-e7d1-7d31-aaa5-429d89c1f2e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c4b77-e7d1-7523-9f15-de7018137fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c4b77-e7d1-7d31-aaa5-429d89c1f2e0" xlink:to="loc_us-gaap_NetIncomeLoss_019c4b77-e7d1-7523-9f15-de7018137fb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c4b77-e7d1-7f59-b061-7641ec359e75" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c4b77-e7d1-7d31-aaa5-429d89c1f2e0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c4b77-e7d1-7f59-b061-7641ec359e75" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="algn-20251231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c4b77-e7d1-7d6c-98a0-36e5dc3e5413" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7b70-8fd8-3232430f45e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c4b77-e7d1-7d6c-98a0-36e5dc3e5413" xlink:to="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7b70-8fd8-3232430f45e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019c4b77-e7d1-790f-88ff-84a4b3f90016" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c4b77-e7d1-7d6c-98a0-36e5dc3e5413" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019c4b77-e7d1-790f-88ff-84a4b3f90016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019c4b77-e7d1-7308-8c2a-7d1dc94675fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c4b77-e7d1-7d6c-98a0-36e5dc3e5413" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019c4b77-e7d1-7308-8c2a-7d1dc94675fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019c4b77-e7d1-72bb-88ec-a6f80665c2e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c4b77-e7d1-7d6c-98a0-36e5dc3e5413" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019c4b77-e7d1-72bb-88ec-a6f80665c2e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019c4b77-e7d1-75b4-8c67-67282d63021e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:to="loc_us-gaap_PreferredStockValue_019c4b77-e7d1-75b4-8c67-67282d63021e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019c4b77-e7d1-75e3-9132-69827ef8748f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:to="loc_us-gaap_CommonStockValue_019c4b77-e7d1-75e3-9132-69827ef8748f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019c4b77-e7d1-7be3-8e5b-0d2c82395ff5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019c4b77-e7d1-7be3-8e5b-0d2c82395ff5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019c4b77-e7d1-7a17-9ee8-78704b3080c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019c4b77-e7d1-7a17-9ee8-78704b3080c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c4b77-e7d1-7fd2-b083-130542134292" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-79e4-b545-49b4b596a456" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c4b77-e7d1-7fd2-b083-130542134292" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7a58-8303-270138c94f9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019c4b77-e7d1-7bc8-b856-9684b12d08ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7a58-8303-270138c94f9f" xlink:to="loc_us-gaap_AccountsPayableCurrent_019c4b77-e7d1-7bc8-b856-9684b12d08ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7699-bd8f-ce46bb4305ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7a58-8303-270138c94f9f" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7699-bd8f-ce46bb4305ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_019c4b77-e7d1-7347-bb2b-d86367daac2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredRevenueCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c4b77-e7d1-7a58-8303-270138c94f9f" xlink:to="loc_us-gaap_DeferredRevenueCurrent_019c4b77-e7d1-7347-bb2b-d86367daac2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c4b77-e7d1-7f67-9a72-3344439926b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c4b77-e7d1-73b8-b006-1a035913c65f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c4b77-e7d1-7f67-9a72-3344439926b5" xlink:to="loc_us-gaap_Liabilities_019c4b77-e7d1-73b8-b006-1a035913c65f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-703e-ac3b-78defde55fee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c4b77-e7d1-7f67-9a72-3344439926b5" xlink:to="loc_us-gaap_StockholdersEquity_019c4b77-e7d1-703e-ac3b-78defde55fee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019c4b77-e7d1-7173-91a4-5a390ca3a5f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c4b77-e7d1-7f67-9a72-3344439926b5" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019c4b77-e7d1-7173-91a4-5a390ca3a5f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-794a-adaf-430f2cccd563" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-794a-adaf-430f2cccd563" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019c4b77-e7d1-7eb4-ac85-2d9885fd4537" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019c4b77-e7d1-7eb4-ac85-2d9885fd4537" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c4b77-e7d1-7ece-996e-800bd337055d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c4b77-e7d1-7ece-996e-800bd337055d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019c4b77-e7d1-7ccf-b924-86549a63c42a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_Goodwill_019c4b77-e7d1-7ccf-b924-86549a63c42a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c4b77-e7d1-7056-b11b-486ce1ce2c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c4b77-e7d1-7056-b11b-486ce1ce2c4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019c4b77-e7d1-7e81-a71b-b826d6f9a5d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019c4b77-e7d1-7e81-a71b-b826d6f9a5d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019c4b77-e7d1-755f-81c4-c44b2d3aa442" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c4b77-e7d1-7bb4-b142-51bb722ff306" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019c4b77-e7d1-755f-81c4-c44b2d3aa442" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c4b77-e7d1-7e78-9f82-1a884abe2e83" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c4b77-e7d1-7e78-9f82-1a884abe2e83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019c4b77-e7d1-758d-8307-4854e2e1daf4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019c4b77-e7d1-758d-8307-4854e2e1daf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c4b77-e7d1-7e60-a25a-b78e20907b68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:to="loc_us-gaap_InventoryNet_019c4b77-e7d1-7e60-a25a-b78e20907b68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7875-a5a2-e74410c869eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7875-a5a2-e74410c869eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c4b77-e7d1-7738-9745-0afa856a214b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c4b77-e7d1-78ed-b6e8-8e5564b619a4" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c4b77-e7d1-7738-9745-0afa856a214b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="algn-20251231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c4b77-e7d1-7b09-8ad1-b5940fc70de4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7618-bee1-46be84bca439" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c4b77-e7d1-7b09-8ad1-b5940fc70de4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7618-bee1-46be84bca439" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-7c42-9ebc-cefa851684ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c4b77-e7d1-7b09-8ad1-b5940fc70de4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-7c42-9ebc-cefa851684ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-7d56-bce8-fc8edd37eec0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c4b77-e7d1-7b09-8ad1-b5940fc70de4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-7d56-bce8-fc8edd37eec0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019c4b77-e7d1-7fc6-8903-33f9488c9458" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c4b77-e7d1-7b09-8ad1-b5940fc70de4" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019c4b77-e7d1-7fc6-8903-33f9488c9458" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c4b77-e7d1-7659-825e-b2725d0dd18f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_NetIncomeLoss_019c4b77-e7d1-7659-825e-b2725d0dd18f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c4b77-e7d1-73fb-8420-2f0907b57c96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c4b77-e7d1-73fb-8420-2f0907b57c96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019c4b77-e7d1-7788-9474-804399f54ad8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019c4b77-e7d1-7788-9474-804399f54ad8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019c4b77-e7d1-766d-9a71-447783b1e6f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_ShareBasedCompensation_019c4b77-e7d1-766d-9a71-447783b1e6f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c4b77-e7d1-7599-8b5c-05ddf8abb206" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c4b77-e7d1-7599-8b5c-05ddf8abb206" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_019c4b77-e7d1-7b02-b3c3-3b583bac4128" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_019c4b77-e7d1-7b02-b3c3-3b583bac4128" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EquitySecuritiesWithoutReadilyDeterminableFairValuePriceAdjustmentsAndImpairmentLossAnnualAmount_019c4b77-e7d1-7b21-b7e6-30270f301c9c" xlink:href="algn-20251231.xsd#algn_EquitySecuritiesWithoutReadilyDeterminableFairValuePriceAdjustmentsAndImpairmentLossAnnualAmount"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_algn_EquitySecuritiesWithoutReadilyDeterminableFairValuePriceAdjustmentsAndImpairmentLossAnnualAmount_019c4b77-e7d1-7b21-b7e6-30270f301c9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019c4b77-e7d1-7712-abc2-cddbe914a2ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019c4b77-e7d1-7712-abc2-cddbe914a2ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c4b77-e7d1-7ace-8ce2-8eb77ad63572" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c4b77-e7d1-7ace-8ce2-8eb77ad63572" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019c4b77-e7d1-7620-a9ec-81d4a4e997c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019c4b77-e7d1-7620-a9ec-81d4a4e997c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c4b77-e7d1-706d-b992-108e9645a925" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c4b77-e7d1-706d-b992-108e9645a925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019c4b77-e7d1-746e-878a-2b703b26d8c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019c4b77-e7d1-746e-878a-2b703b26d8c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019c4b77-e7d1-75bb-8fc1-231c2b9851d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019c4b77-e7d1-75bb-8fc1-231c2b9851d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019c4b77-e7d1-7a3f-8c6c-81b5f52f83f9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019c4b77-e7d1-7a3f-8c6c-81b5f52f83f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019c7354-47c1-7c30-9c8f-9784c17dcaf4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c4b77-e7d1-7551-ae11-0c414ee5daf6" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019c7354-47c1-7c30-9c8f-9784c17dcaf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c4b77-e7d1-79b4-ae38-3da08dd98723" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c4b77-e7d1-79b4-ae38-3da08dd98723" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019c4b77-e7d1-756b-b4f3-a0bb2be7358a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019c4b77-e7d1-756b-b4f3-a0bb2be7358a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019c4b77-e7d1-7c21-97aa-67120a03ec7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019c4b77-e7d1-7c21-97aa-67120a03ec7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019c4b77-e7d1-7612-8d5d-c07da21dd6cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019c4b77-e7d1-7612-8d5d-c07da21dd6cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019c4b77-e7d1-70b3-bb2a-2569d7a1ce88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019c4b77-e7d1-70b3-bb2a-2569d7a1ce88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019c4b77-e7d1-75ad-b5aa-7930c0b36cea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019c4b77-e7d1-75ad-b5aa-7930c0b36cea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_PaymentsToAcquireEquitySecurities_019c4b77-e7d1-7ba3-b076-c48b8f3f2b86" xlink:href="algn-20251231.xsd#algn_PaymentsToAcquireEquitySecurities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c4b77-e7d1-74e3-97dc-6d208449c639" xlink:to="loc_algn_PaymentsToAcquireEquitySecurities_019c4b77-e7d1-7ba3-b076-c48b8f3f2b86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-781b-90cf-b99f179b19a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019c4b77-e7d1-714b-ba52-641e6ab7b02b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-781b-90cf-b99f179b19a8" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019c4b77-e7d1-714b-ba52-641e6ab7b02b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019c4b77-e7d1-7990-9add-ad9236f3ec4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-781b-90cf-b99f179b19a8" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019c4b77-e7d1-7990-9add-ad9236f3ec4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_PaymentsForProceedsFromForEquityForwardContractFinancingActivities_019c4b77-e7d1-7629-9525-b64b152ea853" xlink:href="algn-20251231.xsd#algn_PaymentsForProceedsFromForEquityForwardContractFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-781b-90cf-b99f179b19a8" xlink:to="loc_algn_PaymentsForProceedsFromForEquityForwardContractFinancingActivities_019c4b77-e7d1-7629-9525-b64b152ea853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019c4b77-e7d1-7027-9a57-74e42223124f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c4b77-e7d1-781b-90cf-b99f179b19a8" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019c4b77-e7d1-7027-9a57-74e42223124f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/FinancialInstrumentsCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#FinancialInstrumentsCashCashEquivalentsandMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/FinancialInstrumentsCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSale_019c4b77-e7d1-7cb9-b67d-6db1f5a33ed4" xlink:href="algn-20251231.xsd#algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSale"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-258b-7c86-85fe-c909c42bb683" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSale_019c4b77-e7d1-7cb9-b67d-6db1f5a33ed4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-258b-7c86-85fe-c909c42bb683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAmortizedCost_019c4b77-e7d1-75e3-b3e1-8c66e1e98bdc" xlink:href="algn-20251231.xsd#algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_CashAndCashEquivalentsAmortizedCost_019c4b77-e7d1-727b-8827-f605583234bd" xlink:href="algn-20251231.xsd#algn_CashAndCashEquivalentsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAmortizedCost_019c4b77-e7d1-75e3-b3e1-8c66e1e98bdc" xlink:to="loc_algn_CashAndCashEquivalentsAmortizedCost_019c4b77-e7d1-727b-8827-f605583234bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-874c-7c6b-b555-866b8fd3b182" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_CashAndCashEquivalentsAmortizedCost_019c7372-874c-7301-96b8-727e67ef2c70" xlink:href="algn-20251231.xsd#algn_CashAndCashEquivalentsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-874c-7c6b-b555-866b8fd3b182" xlink:to="loc_algn_CashAndCashEquivalentsAmortizedCost_019c7372-874c-7301-96b8-727e67ef2c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019c7372-874c-7d48-bd56-bc40345f85e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-874c-7c6b-b555-866b8fd3b182" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019c7372-874c-7d48-bd56-bc40345f85e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c7372-874c-7e7c-ad9c-1fc27bb37f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7372-874c-7c6b-b555-866b8fd3b182" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c7372-874c-7e7c-ad9c-1fc27bb37f6f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/FinancialInstrumentsFairValueMeasuredOnARecurringBasisDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#FinancialInstrumentsFairValueMeasuredOnARecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/FinancialInstrumentsFairValueMeasuredOnARecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019c4b77-e7d1-7013-b934-1c9e9bc60ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019c4b77-e7d1-7ec2-9406-13adabdbd424" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019c4b77-e7d1-7013-b934-1c9e9bc60ed7" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019c4b77-e7d1-7ec2-9406-13adabdbd424" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BalanceSheetComponentsInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c4b77-e7d1-7c87-8111-95c588808684" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019c4b77-e7d1-78d4-89eb-803939138b97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c4b77-e7d1-7c87-8111-95c588808684" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019c4b77-e7d1-78d4-89eb-803939138b97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019c4b77-e7d1-7947-a6d3-b5d4acbfeffb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c4b77-e7d1-7c87-8111-95c588808684" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019c4b77-e7d1-7947-a6d3-b5d4acbfeffb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019c4b77-e7d1-7b45-9a11-fbb8d651b108" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c4b77-e7d1-7c87-8111-95c588808684" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019c4b77-e7d1-7b45-9a11-fbb8d651b108" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7210-9095-61b363a1b47f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019c4b77-e7d1-753e-9198-216cd1760d60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7210-9095-61b363a1b47f" xlink:to="loc_us-gaap_OtherAssetsCurrent_019c4b77-e7d1-753e-9198-216cd1760d60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValueAddedTaxReceivableCurrent_019c4b77-e7d1-712d-8ec2-286a39f563de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ValueAddedTaxReceivableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7210-9095-61b363a1b47f" xlink:to="loc_us-gaap_ValueAddedTaxReceivableCurrent_019c4b77-e7d1-712d-8ec2-286a39f563de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_019c4b77-e7d1-78e2-9ac2-5baefce06232" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c4b77-e7d1-7210-9095-61b363a1b47f" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_019c4b77-e7d1-78e2-9ac2-5baefce06232" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BalanceSheetComponentsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BalanceSheetComponentsPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BalanceSheetComponentsPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019c4b77-e7d1-793e-b77d-0f9bc2ef2322" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019c4b77-e7d1-7758-a454-78c57d70bfc0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019c4b77-e7d1-793e-b77d-0f9bc2ef2322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019c4b77-e7d1-7758-a454-78c57d70bfc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019c4b77-e7d1-787c-8041-c778fc7d0ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019c4b77-e7d1-793e-b77d-0f9bc2ef2322" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019c4b77-e7d1-787c-8041-c778fc7d0ba6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BalanceSheetComponentsAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BalanceSheetComponentsAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BalanceSheetComponentsAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_019c4b77-e7d1-7122-85f3-9f76b8147cbe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_019c4b77-e7d1-7122-85f3-9f76b8147cbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019c4b77-e7d1-78dd-9766-022873c07759" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019c4b77-e7d1-78dd-9766-022873c07759" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_AccruedFixedAssetsCurrent_019c4b77-e7d1-7066-9e0b-3d93ae7fa340" xlink:href="algn-20251231.xsd#algn_AccruedFixedAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_algn_AccruedFixedAssetsCurrent_019c4b77-e7d1-7066-9e0b-3d93ae7fa340" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019c4b77-e7d1-7530-8d7c-d86770569984" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019c4b77-e7d1-7530-8d7c-d86770569984" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c4b77-e7d1-7679-96f8-0afa1b6c5cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c4b77-e7d1-7679-96f8-0afa1b6c5cf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019c4b77-e7d1-788b-b210-2852dd7c1259" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019c4b77-e7d1-788b-b210-2852dd7c1259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_019c4b77-e7d1-7bd3-8fb6-b8d2f600e6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c4b77-e7d1-7ff6-a77e-6c9ea0448380" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_019c4b77-e7d1-7bd3-8fb6-b8d2f600e6d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/LeasesComponentsofLeaseExpenseDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#LeasesComponentsofLeaseExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/LeasesComponentsofLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019c4b77-e7d1-7150-8ea1-52b51fad93b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019c4b77-e7d1-7fc4-90c3-1eb42b32518b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c4b77-e7d1-7150-8ea1-52b51fad93b4" xlink:to="loc_us-gaap_OperatingLeaseCost_019c4b77-e7d1-7fc4-90c3-1eb42b32518b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019c4b77-e7d1-79b9-bebd-9237d94dc19c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c4b77-e7d1-7150-8ea1-52b51fad93b4" xlink:to="loc_us-gaap_VariableLeaseCost_019c4b77-e7d1-79b9-bebd-9237d94dc19c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/LeasesScheduleofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#LeasesScheduleofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/LeasesScheduleofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019c4b77-e7d1-7d99-8d91-a6f0af878780" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019c4b77-e7d1-7d99-8d91-a6f0af878780" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019c4b77-e7d1-7743-aca5-165faa8828d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019c4b77-e7d1-7743-aca5-165faa8828d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019c4b77-e7d1-7b91-b022-bc70cb7de663" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019c4b77-e7d1-7b91-b022-bc70cb7de663" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019c4b77-e7d1-7dda-aa2b-c4d9a5441be5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019c4b77-e7d1-7dda-aa2b-c4d9a5441be5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019c4b77-e7d1-7bb6-a20b-b2100a0326c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019c4b77-e7d1-7bb6-a20b-b2100a0326c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019c4b77-e7d1-7303-bed1-d8f2bd908211" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7307-9ae7-1f572725405d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019c4b77-e7d1-7303-bed1-d8f2bd908211" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/LeasesScheduleofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="algn-20251231.xsd#LeasesScheduleofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/LeasesScheduleofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7645-9663-6786c39e959f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019c4b77-e7d1-7ddc-9ec5-6bbeded4688e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7645-9663-6786c39e959f" xlink:to="loc_us-gaap_OperatingLeaseLiability_019c4b77-e7d1-7ddc-9ec5-6bbeded4688e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019c4b77-e7d1-7a0a-82d7-9137ed5e648a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c4b77-e7d1-7645-9663-6786c39e959f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019c4b77-e7d1-7a0a-82d7-9137ed5e648a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/LeasesPropertyPlantandEquipmentUnderOperatingLeasesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#LeasesPropertyPlantandEquipmentUnderOperatingLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/LeasesPropertyPlantandEquipmentUnderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseNet_019c4b77-e7d1-7538-a9e3-e32637168df2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAccumulatedDepreciation_019c4b77-e7d1-7cd4-9015-e1c45761f47f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAccumulatedDepreciation"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseNet_019c4b77-e7d1-7538-a9e3-e32637168df2" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAccumulatedDepreciation_019c4b77-e7d1-7cd4-9015-e1c45761f47f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross_019c4b77-e7d1-7998-9215-c512eb426987" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseNet_019c4b77-e7d1-7538-a9e3-e32637168df2" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross_019c4b77-e7d1-7998-9215-c512eb426987" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/LeasesLeasePaymentsDueDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#LeasesLeasePaymentsDueDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/LeasesLeasePaymentsDueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c4b77-e7d1-7bfa-8623-dda8ce123e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_019c4b77-e7d1-76ea-a23b-6a62375b7b69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c4b77-e7d1-7bfa-8623-dda8ce123e0e" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_019c4b77-e7d1-76ea-a23b-6a62375b7b69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_019c4b77-e7d1-7990-9239-73dd53cac792" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c4b77-e7d1-7bfa-8623-dda8ce123e0e" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_019c4b77-e7d1-7990-9239-73dd53cac792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_019c4b77-e7d1-7d45-94ea-ab588a680827" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c4b77-e7d1-7bfa-8623-dda8ce123e0e" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_019c4b77-e7d1-7d45-94ea-ab588a680827" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BusinessCombinationFairValueofConsiderationTransferredDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BusinessCombinationFairValueofConsiderationTransferredDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BusinessCombinationFairValueofConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_019c4b77-e7d1-74fe-ac74-03d9c9f381a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_BusinessCombinationConsiderationTransferredSettlementOfLiability_019c4b77-e7d1-7cfd-b66f-75c36a29ae48" xlink:href="algn-20251231.xsd#algn_BusinessCombinationConsiderationTransferredSettlementOfLiability"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_019c4b77-e7d1-74fe-ac74-03d9c9f381a8" xlink:to="loc_algn_BusinessCombinationConsiderationTransferredSettlementOfLiability_019c4b77-e7d1-7cfd-b66f-75c36a29ae48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_019c4b77-e7d1-7117-b3a3-c2fdf289a240" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_019c4b77-e7d1-74fe-ac74-03d9c9f381a8" xlink:to="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_019c4b77-e7d1-7117-b3a3-c2fdf289a240" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_019c4b77-e7d1-749b-a02f-ef89c15bcd48" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_019c4b77-e7d1-74fe-ac74-03d9c9f381a8" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_019c4b77-e7d1-749b-a02f-ef89c15bcd48" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/BusinessCombinationAllocationofPurchasePricetoAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#BusinessCombinationAllocationofPurchasePricetoAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/BusinessCombinationAllocationofPurchasePricetoAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019c4b77-e7d1-7f94-8bb3-564a795b31d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019c4b77-e7d1-7f94-8bb3-564a795b31d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019c4b77-e7d1-726f-9b07-be55fac5c859" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019c4b77-e7d1-726f-9b07-be55fac5c859" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetWorkingCapital_019c4b77-e7d1-70d6-86d1-190a7e4b8114" xlink:href="algn-20251231.xsd#algn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetWorkingCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_algn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetWorkingCapital_019c4b77-e7d1-70d6-86d1-190a7e4b8114" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019c4b77-e7d1-7341-bc13-5a8d25d98971" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019c4b77-e7d1-7341-bc13-5a8d25d98971" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019c4b77-e7d1-7af0-aff4-0728baea6164" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_us-gaap_Goodwill_019c4b77-e7d1-7af0-aff4-0728baea6164" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019c4b77-e7d1-79cb-a442-da06ff33e6ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019c4b77-e7d1-7163-8384-bdd83f8f9a45" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019c4b77-e7d1-79cb-a442-da06ff33e6ef" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/GoodwillandIntangibleAssetsIntangibleAssetsDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#GoodwillandIntangibleAssetsIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/GoodwillandIntangibleAssetsIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-71a8-954f-ce53bd2486c2" xlink:href="algn-20251231.xsd#algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c4b77-e7d1-7bf3-9cf8-ce881c808276" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-71a8-954f-ce53bd2486c2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c4b77-e7d1-7bf3-9cf8-ce881c808276" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c4b77-e7d1-73c6-aa62-896363eb5bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-71a8-954f-ce53bd2486c2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c4b77-e7d1-73c6-aa62-896363eb5bb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_FiniteLivedIntangibleAssetsAccumulatedImpairmentLoss_019c4b77-e7d1-718c-8756-eec0e61aa465" xlink:href="algn-20251231.xsd#algn_FiniteLivedIntangibleAssetsAccumulatedImpairmentLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-71a8-954f-ce53bd2486c2" xlink:to="loc_algn_FiniteLivedIntangibleAssetsAccumulatedImpairmentLoss_019c4b77-e7d1-718c-8756-eec0e61aa465" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c4b77-e7d1-70c7-852e-bd9d7596ad43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss1_019c4b77-e7d1-7696-a8a3-2e4c88c9274c" xlink:href="algn-20251231.xsd#algn_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c4b77-e7d1-70c7-852e-bd9d7596ad43" xlink:to="loc_algn_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss1_019c4b77-e7d1-7696-a8a3-2e4c88c9274c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-7e7f-bac2-58e6927a19cd" xlink:href="algn-20251231.xsd#algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c4b77-e7d1-70c7-852e-bd9d7596ad43" xlink:to="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-7e7f-bac2-58e6927a19cd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/GoodwillandIntangibleAssetsTotalEstimatedAnnualFutureAmortizationExpensefortheAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#GoodwillandIntangibleAssetsTotalEstimatedAnnualFutureAmortizationExpensefortheAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/GoodwillandIntangibleAssetsTotalEstimatedAnnualFutureAmortizationExpensefortheAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:href="algn-20251231.xsd#algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019c4b77-e7d1-737f-a91a-fc4267ed17f9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019c4b77-e7d1-737f-a91a-fc4267ed17f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019c4b77-e7d1-7d9c-a5f8-0f60737a826f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019c4b77-e7d1-7d9c-a5f8-0f60737a826f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019c4b77-e7d1-7136-803b-3c284fcb679c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019c4b77-e7d1-7136-803b-3c284fcb679c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019c4b77-e7d1-7368-af3a-6f205903921d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019c4b77-e7d1-7368-af3a-6f205903921d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019c4b77-e7d1-74e4-9a1d-361d0ecfd8fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019c4b77-e7d1-74e4-9a1d-361d0ecfd8fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019c4b77-e7d1-7d11-a749-36c8ad9005b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_algn_FiniteLivedIntangibleAssetsNetBeforeForeignCurrencyTranslationGainLoss_019c4b77-e7d1-736c-b669-7d18c533b8cb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019c4b77-e7d1-7d11-a749-36c8ad9005b3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesDomesticandForeignComponentsofIncomelossBeforeProvisionforIncomeTaxesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesDomesticandForeignComponentsofIncomelossBeforeProvisionforIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesDomesticandForeignComponentsofIncomelossBeforeProvisionforIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e7d2-7bf3-b551-b14c702a3da8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_019c4b77-e7d2-7731-a78d-a5265799a76a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e7d2-7bf3-b551-b14c702a3da8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_019c4b77-e7d2-7731-a78d-a5265799a76a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_019c4b77-e7d2-72a4-9c2c-a1587ae6fe8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c4b77-e7d2-7bf3-b551-b14c702a3da8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_019c4b77-e7d2-72a4-9c2c-a1587ae6fe8f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesProvisionforBenefitfromIncomeTaxesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesProvisionforBenefitfromIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesProvisionforBenefitfromIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7a4f-ad51-d2f111f91f81" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_019c4b77-e7d2-77c9-bf2e-20e33b941cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7a4f-ad51-d2f111f91f81" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_019c4b77-e7d2-77c9-bf2e-20e33b941cb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_019c4b77-e7d2-71c2-ac7e-a540c52210c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7a4f-ad51-d2f111f91f81" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_019c4b77-e7d2-71c2-ac7e-a540c52210c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-71d0-8ef6-d9d02cb48df5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_019c4b77-e7d2-74ec-9d9f-0353ed1ff389" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-71d0-8ef6-d9d02cb48df5" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_019c4b77-e7d2-74ec-9d9f-0353ed1ff389" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_019c4b77-e7d2-7297-bd11-4f39cf46e9c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-71d0-8ef6-d9d02cb48df5" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_019c4b77-e7d2-7297-bd11-4f39cf46e9c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7911-ac25-021466789855" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_019c4b77-e7d2-7d0c-b3b6-be7044f0572b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7911-ac25-021466789855" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_019c4b77-e7d2-7d0c-b3b6-be7044f0572b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_019c4b77-e7d2-7077-a0e6-7732c8e16aee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_019c4b77-e7d2-7911-ac25-021466789855" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_019c4b77-e7d2-7077-a0e6-7732c8e16aee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c4b77-e7d2-7cac-8218-481b9995666f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c4b77-e7d2-7cac-8218-481b9995666f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019c4b77-e7d2-7085-a00a-8933c6c56c0a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019c4b77-e7d2-7085-a00a-8933c6c56c0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019c4b77-e7d2-7c1c-9854-6f3080f72c23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019c4b77-e7d2-7c1c-9854-6f3080f72c23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EffectiveIncomeTaxRateReconciliationCantonTaxAmount_019c6a53-1c5d-76ec-9ad8-43d8de6946c2" xlink:href="algn-20251231.xsd#algn_EffectiveIncomeTaxRateReconciliationCantonTaxAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_algn_EffectiveIncomeTaxRateReconciliationCantonTaxAmount_019c6a53-1c5d-76ec-9ad8-43d8de6946c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_019c6a53-1c5d-7a9f-bdf2-1e1e8fe02bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_019c6a53-1c5d-7a9f-bdf2-1e1e8fe02bdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_019c6a53-1c5d-70e2-80a0-708dbb5dbfc6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_019c6a53-1c5d-70e2-80a0-708dbb5dbfc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_019c6a53-1c5d-78b9-bcf2-0c04875849e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_019c6a53-1c5d-78b9-bcf2-0c04875849e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EffectiveIncomeTaxRateReconciliationSubpartFAmount_019c6a53-1c5d-718b-a746-051b72eca06b" xlink:href="algn-20251231.xsd#algn_EffectiveIncomeTaxRateReconciliationSubpartFAmount"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_algn_EffectiveIncomeTaxRateReconciliationSubpartFAmount_019c6a53-1c5d-718b-a746-051b72eca06b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount_019c6a53-1c5d-758d-bf74-f9ef2c1e6d72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount_019c6a53-1c5d-758d-bf74-f9ef2c1e6d72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount_019c6a53-1c5d-765c-a13b-e2bcda635b10" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount_019c6a53-1c5d-765c-a13b-e2bcda635b10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_019c6a53-1c5d-737d-a011-a2520977633a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_019c6a53-1c5d-737d-a011-a2520977633a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-1c5d-7c34-86de-f6bc7b5d3078" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-1c5d-7c34-86de-f6bc7b5d3078" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_019c6a53-1c5d-7a61-96c6-66fa397dd6ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_019c6a53-1c5d-7a61-96c6-66fa397dd6ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_019c6a53-1c5d-7e79-9384-c8a0bf20952f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxContingencies"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c4b77-e7d2-71ed-9ff5-bbe3bcabe20c" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_019c6a53-1c5d-7e79-9384-c8a0bf20952f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c4b77-e89f-701e-ba67-44e9f97fe95f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c4b77-e89f-701e-ba67-44e9f97fe95f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c4b77-e89f-7239-823d-d50c4e28fbbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c4b77-e89f-7239-823d-d50c4e28fbbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c4b77-e89f-7b3c-a692-fb0a5685ec11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c4b77-e89f-7b3c-a692-fb0a5685ec11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EffectiveIncomeTaxRateReconciliationCantonTaxPercent_019c4b77-e89f-7241-80ca-7cd8874e777b" xlink:href="algn-20251231.xsd#algn_EffectiveIncomeTaxRateReconciliationCantonTaxPercent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_algn_EffectiveIncomeTaxRateReconciliationCantonTaxPercent_019c4b77-e89f-7241-80ca-7cd8874e777b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_019c4b77-e89f-7ffc-9e98-979311ec7c42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_019c4b77-e89f-7ffc-9e98-979311ec7c42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c4b77-e89f-7eae-b17d-8230d9b4afef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c4b77-e89f-7eae-b17d-8230d9b4afef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_019c4b77-e89f-7c89-97e2-af0f3a930cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_019c4b77-e89f-7c89-97e2-af0f3a930cfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EffectiveIncomeTaxRateReconciliationSubpartFPercent_019c4b77-e89f-7279-8b7e-0884fcd6afc9" xlink:href="algn-20251231.xsd#algn_EffectiveIncomeTaxRateReconciliationSubpartFPercent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_algn_EffectiveIncomeTaxRateReconciliationSubpartFPercent_019c4b77-e89f-7279-8b7e-0884fcd6afc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_019c6a53-7c7b-7905-8907-5cd36554b77e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_019c6a53-7c7b-7905-8907-5cd36554b77e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent_019c6a53-7c7b-7b63-96e3-97bcbf66046d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent_019c6a53-7c7b-7b63-96e3-97bcbf66046d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_019c6a53-7c7b-7c44-a8a9-b0d991a4f23c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_019c6a53-7c7b-7c44-a8a9-b0d991a4f23c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-7c7b-76cc-aedf-961a6050d233" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-7c7b-76cc-aedf-961a6050d233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_019c6a53-7c7b-7a81-8072-05d6847335a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_019c6a53-7c7b-7a81-8072-05d6847335a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_019c6a53-7c7b-7fab-aa8f-d141be86c7e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c4b77-e89f-7584-aee9-127c7a0767e2" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_019c6a53-7c7b-7fab-aa8f-d141be86c7e4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c6a53-ccec-7892-b3cc-116828d148f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c6a53-ccec-7892-b3cc-116828d148f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c6a53-ccec-76e8-8df6-460daa309245" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c6a53-ccec-76e8-8df6-460daa309245" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_EffectiveTaxRateReconciliationRepatriationOfForeignEarningsOffsetByTaxCreditForeignPercent_019c6a53-ccec-71d3-b147-d5123ef24592" xlink:href="algn-20251231.xsd#algn_EffectiveTaxRateReconciliationRepatriationOfForeignEarningsOffsetByTaxCreditForeignPercent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_algn_EffectiveTaxRateReconciliationRepatriationOfForeignEarningsOffsetByTaxCreditForeignPercent_019c6a53-ccec-71d3-b147-d5123ef24592" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c6a53-ccec-790d-8b5f-bc160ff3a883" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c6a53-ccec-790d-8b5f-bc160ff3a883" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-ccec-7dd6-a8eb-f708b88f1b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c6a53-ccec-7dd6-a8eb-f708b88f1b5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements_019c6a53-ccec-7d60-a4ef-13f22ec255b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements_019c6a53-ccec-7d60-a4ef-13f22ec255b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c6a53-ccec-7e5e-bc22-54412f7dd57d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c6a53-ccec-7e5e-bc22-54412f7dd57d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c6a53-ccec-70a9-9fcb-51b0a265b9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c6a53-ccec-7022-98b1-c1f35ac3026a" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c6a53-ccec-70a9-9fcb-51b0a265b9f8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c4b77-e89f-762f-834e-1cd3903d12e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7486-bea8-6161ffb2b47f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c4b77-e89f-762f-834e-1cd3903d12e8" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7486-bea8-6161ffb2b47f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_019c4b77-e89f-7ca3-847a-06678c6096c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c4b77-e89f-762f-834e-1cd3903d12e8" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_019c4b77-e89f-7ca3-847a-06678c6096c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_019c4b77-e89f-7ce2-be37-8c75ff0a3704" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-79f8-b3f1-4fce9359f426" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_019c4b77-e89f-7ce2-be37-8c75ff0a3704" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-79f8-b3f1-4fce9359f426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c4b77-e89f-71a6-be18-a063aa4bb5ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_019c4b77-e89f-7ce2-be37-8c75ff0a3704" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c4b77-e89f-71a6-be18-a063aa4bb5ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_019c4b77-e89f-733f-bcbf-a3829618a9f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_019c4b77-e89f-733f-bcbf-a3829618a9f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_019c4b77-e89f-77e3-b98e-ce77447b8346" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_019c4b77-e89f-77e3-b98e-ce77447b8346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_019c4b77-e89f-71d4-aff7-2a7d39074ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_019c4b77-e89f-71d4-aff7-2a7d39074ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_019c4b77-e89f-7d79-9709-6865aecd5284" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_019c4b77-e89f-7d79-9709-6865aecd5284" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_019c4b77-e89f-7804-beae-41c0e8e5a0d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_019c4b77-e89f-7804-beae-41c0e8e5a0d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_algn_DeferredTaxAssetsNetOperatingAndCapitalLossCarryforwards_019c4b77-e89f-7045-bfa3-6ef8479f3d61" xlink:href="algn-20251231.xsd#algn_DeferredTaxAssetsNetOperatingAndCapitalLossCarryforwards"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_algn_DeferredTaxAssetsNetOperatingAndCapitalLossCarryforwards_019c4b77-e89f-7045-bfa3-6ef8479f3d61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_019c4b77-e89f-7ec2-8218-8616038182eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_019c4b77-e89f-76de-9d5c-bd204b28baaf" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_019c4b77-e89f-7ec2-8218-8616038182eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7755-bfb8-755482f4a7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_019c4b77-e89f-7fa6-b41b-93cd2e34c152" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7755-bfb8-755482f4a7a3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_019c4b77-e89f-7fa6-b41b-93cd2e34c152" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_019c4b77-e89f-7cea-b2c8-a8b099641974" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7755-bfb8-755482f4a7a3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_019c4b77-e89f-7cea-b2c8-a8b099641974" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_019c4b77-e89f-7734-8ae8-a18271591320" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_019c4b77-e89f-7755-bfb8-755482f4a7a3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_019c4b77-e89f-7734-8ae8-a18271591320" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/IncomeTaxesScheduleofIncomeTaxPaidDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#IncomeTaxesScheduleofIncomeTaxPaidDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/IncomeTaxesScheduleofIncomeTaxPaidDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_019c6a5a-b2f9-7456-85be-c14d1ffcaf8d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxesPaidNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_019c6a5a-b2f9-7280-bf77-d40bab5bbba9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidFederalAfterRefundReceived"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_019c6a5a-b2f9-7456-85be-c14d1ffcaf8d" xlink:to="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_019c6a5a-b2f9-7280-bf77-d40bab5bbba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_019c6a5a-b2f9-7087-b052-d5ae4319f27f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_019c6a5a-b2f9-7456-85be-c14d1ffcaf8d" xlink:to="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_019c6a5a-b2f9-7087-b052-d5ae4319f27f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidForeignAfterRefundReceived_019c6a5a-b2f9-79da-a236-14a88cb9bad0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidForeignAfterRefundReceived"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_019c6a5a-b2f9-7456-85be-c14d1ffcaf8d" xlink:to="loc_us-gaap_IncomeTaxPaidForeignAfterRefundReceived_019c6a5a-b2f9-79da-a236-14a88cb9bad0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aligntech.com/role/NetIncomeperShareDetails" xlink:type="simple" xlink:href="algn-20251231.xsd#NetIncomeperShareDetails"/>
  <link:calculationLink xlink:role="http://www.aligntech.com/role/NetIncomeperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c4b77-e89f-79f5-bdcd-916157afe5a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c4b77-e89f-7e1e-bff5-186917d2c707" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c4b77-e89f-79f5-bdcd-916157afe5a6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c4b77-e89f-7e1e-bff5-186917d2c707" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019c4b77-e89f-790b-b117-f46eb77a108d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c4b77-e89f-79f5-bdcd-916157afe5a6" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019c4b77-e89f-790b-b117-f46eb77a108d" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
